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For each 10 gallons of water, empty one packet directly into aquarium. Repeat dose after 48 hours. Wait another 48 hours then change 25% of the aquarium water and add fresh activated carbon or replace filter cartridge. Directions for use for liquid: Remove activated carbon from filter and continue aeration. Add 5 ml. per 5 gallons of aquarium water. Repeat dose 48 hours. Wait another 48 hours then change 25% of the aquarium water and add fresh activated carbon.